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Article

A mode of regulation of beta-catenin signaling activity in Xenopus embryos independent of its levels.

Developmental biology - 15 Jul 2000

Guger K A, Gumbiner B M

Abstract excerpt

The signaling activity of beta-catenin is thought to be regulated by phosphorylation of a cluster of N-terminal serines, putative sites for GSK3beta. In the prevailing model in the literature, GSK3beta-dependent phosphorylation of these sites targets beta-catenin for ubiquitin-mediated degradation. Wnt signaling inhibits GSK3beta activity and this blocks degradation, allowing beta-catenin to accumulate and...

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PMID: 10882528
DOI: 10.1006/dbio.2000.9770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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