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Article

Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis.

Science signaling - 10 Apr 2012

Jeong Woo-Jeong, Yoon Juyong, Park Jong-Chan, Lee Soung-Hoon, Lee Seung-Hoon, Kaduwal Saluja, Kim Hoguen, Yoon Jong-Bok, Choi Kang-Yell

Abstract excerpt

Although the guanosine triphosphate/guanosine diphosphate loading switch is a major regulatory mechanism that controls the activity of the guanosine triphosphatase Ras, we report a distinct mechanism for regulating Ras activity through phosphorylation-mediated degradation and describe the role of...

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Source

Identifiers

PMID: 22494971
DOI: 10.1126/scisignal.2002242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22494971-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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