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Article

Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis.

Science signaling - 10 Apr 2012

Jeong Woo-Jeong, Yoon Juyong, Park Jong-Chan, Lee Soung-Hoon, Lee Seung-Hoon, Kaduwal Saluja, Kim Hoguen, Yoon Jong-Bok, Choi Kang-Yell

Abstract excerpt

Although the guanosine triphosphate/guanosine diphosphate loading switch is a major regulatory mechanism that controls the activity of the guanosine triphosphatase Ras, we report a distinct mechanism for regulating Ras activity through phosphorylation-mediated degradation and describe the role of this second regulatory mechanism in the suppression of cellular transformation and tumors induced by Ras mutations. We...

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PMID: 22494971
DOI: 10.1126/scisignal.2002242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis.PMID 22494971Read ↗

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