Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cleavage of beta-catenin by calpain in prostate and mammary tumor cells.

Cancer research - 15 Oct 2004

Rios-Doria Jonathan, Kuefer Rainer, Ethier Stephen P, Day Mark L

Abstract excerpt

Mutations in the NH(2)-terminal regulatory domain of the beta-catenin gene lead to aberrant stabilization and accumulation of the protein and increased TCF/LEF-dependent transcription. Although these mutations are common in some cancers, they are infrequent in prostate and breast cancer. We have found that metastatic prostate cancer specimens, obtained through a rapid autopsy tissue procurement program, expressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Calpain
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Ionomycin

Share to Prostatic Neoplasms

Share to TCF Transcription Factors

Share to Transcription Factor 7-Like 2 Protein

Source

Identifiers

PMID: 15492240
DOI: 10.1158/0008-5472.CAN-04-1048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Cleavage of beta-catenin by calpain in prostate and mammary tumor cells.PMID 15492240Read ↗

Detection and analysis of ?-catenin mutations in prostate cancerSemantic proximity Read ↗

Beta-catenin cleavage enhances transcriptional activation.Semantic proximity Read ↗

The calpain system is involved in the constitutive regulation of beta-catenin signaling functions.Semantic proximity Read ↗

Activation of β-catenin signaling in androgen receptor-negative prostate cancer cells.Semantic proximity Read ↗

Decreased expression of catenins (? and ?), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomasSemantic proximity Read ↗

Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction.Semantic proximity Read ↗

Beta-catenin affects androgen receptor transcriptional activity and ligand specificity.Semantic proximity Read ↗

Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone.Semantic proximity Read ↗

Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.Semantic proximity Read ↗

Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.