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Article

Replication-competent chimeric hepatitis C virus subgenomic replicons.

Intervirology - 1 Jan 2005

Lemm Julie A, Liu Mengping, Rose Ronald E, Fridell Robert, O'Boyle Ii Donald R, Colonno Richard, Gao Min

Abstract excerpt

OBJECTIVE: To utilize chimeric hepatitis C virus (HCV) replicons to select adaptive mutation(s) that allow replication of a genotype 1a replicon. METHODS: We used a genetic approach to gradually apply selective pressure by generating chimeric replicons through sequential replacement of nonstructural genes of a 1b replicon with genotype 1a sequences. RESULTS: A chimeric replicon containing a genotype 1a NS5A...

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Identifiers

PMID: 15812193
DOI: 10.1159/000081747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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