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Article

Replication studies using genotype 1a subgenomic hepatitis C virus replicons.

Journal of virology - 1 May 2003

Gu Baohua, Gates Adam T, Isken Olaf, Behrens Sven-Erik, Sarisky Robert T

Abstract excerpt

Recently, cell-based replicon systems for hepatitis C virus (HCV), in which the nonstructural proteins stably replicate subgenomic viral RNA in Huh7 cells, were developed. To date, one limitation of using these replicon systems to advance drug discovery is the inability of other genotypic derivatives, beyond those of two distinct strains of genotype 1b (HCV-N and Con1), to stably replicate in Huh7 cells. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12692237
DOI: 10.1128/jvi.77.9.5352-5359.2003
PMCID: PMC153987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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