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Article

Development of a chimeric replicon system for phenotypic analysis of NS3 protease sequences from HCV clinical isolates.

Antiviral therapy - 1 Jan 2011

Sheaffer Amy K, Lee Min S, Hernandez Dennis, Chaniewski Susan, Yu Fei, Falk Paul, Friborg Jacques, Zhai Guangzhi, McPhee Fiona

Abstract excerpt

BACKGROUND: To support clinical development of HCV non-structural protein (NS) 3 protease inhibitors (PIs), phenotypic monitoring of patient isolates is a prerequisite for understanding the emergence of resistance. HCV isolates typically fail to replicate in cell culture, necessitating the use of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21817192
DOI: 10.3851/IMP1825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21817192-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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