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Regulation of Id2 expression by CCAAT/enhancer binding protein

23 Mar 2005

Abstract excerpt

Mice deficient for Id2, a negative regulator of basic helix-loop-helix (bHLH) transcription factors, exhibit a defect in lactation due to impaired lobuloalveolar development during pregnancy, similar to the mice lacking the CCAAT enhancer binding protein (C/EBP) beta. Here, we show that Id2 is a direct target of C/EBPbeta. Translocation of C/EBPbeta into the nucleus, which was achieved by using a system utilizing...

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PMID: 15809228
DOI: 10.1093/nar/gki339

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