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Article

Id-1, ITF-2, and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation, and apoptosis.

The Journal of biological chemistry - 19 Oct 2001

Parrinello S, Lin C Q, Murata K, Itahana Y, Singh J, Krtolica A, Campisi J, Desprez P Y

Abstract excerpt

Mammary epithelial cells proliferate, invade the stroma, differentiate, and die in adult mammals by mechanisms that are poorly understood. We found that Id-1, an inhibitor of basic helix-loop-helix transcription factors, regulates mammary epithelial cell growth, differentiation, and invasion in culture. Here, we show that Id-1 is expressed highly during mammary development in virgin mice and during early...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11498533
DOI: 10.1074/jbc.M104473200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Id-1, ITF-2, and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation, and apoptosis.PMID 11498533Read ↗

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A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1.Semantic proximity Read ↗

Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factorsSemantic proximity Read ↗

Id proteins in epithelial cells.Semantic proximity Read ↗

TGF-β and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell TransitionSemantic proximity Read ↗

Id2 and Id3 Define the Potency of Cell Proliferation and Differentiation Responses to Transforming Growth Factor β and Bone Morphogenetic ProteinSemantic proximity Read ↗

Overexpression of Inhibitor of DNA-Binding 2 Attenuates Pulmonary Fibrosis through Regulation of c-Abl and TwistSemantic proximity Read ↗

Characterization of Gene Expression Signatures for the Identification of Cellular Heterogeneity in the Developing Mammary GlandSemantic proximity Read ↗

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