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Article

Estrogen-regulated prohibitin is required for mouse uterine development and adult function.

Endocrinology - 1 Mar 2011

He Bin, Kim Tae Hoon, Kommagani Ramakrishna, Feng Qin, Lanz Rainer B, Jeong Jae-Wook, DeMayo Francesco J, Katzenellenbogen Benita S, Lydon John P, O'Malley Bert W

Abstract excerpt

Estrogen signaling is pivotal for maintenance of female reproductive function in mammals. The physiological role of estrogen is mediated by estrogen receptors (ERs) and the steroid receptor coactivator family of transcriptional coregulators. Ablation of steroid receptor coactivator and ER coactivators in mice causes impaired female reproductive function. Recently we reported that prohibitin (PHB) can function as...

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Identifiers

PMID: 21209023
DOI: 10.1210/en.2010-0732
PMCID: PMC3040048

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