Article
C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.
Genes & development - 15 Jun 1998
Seagroves T N, Krnacik S, Raught B, Gay J, Burgess-Beusse B, Darlington G J, Rosen J M
Abstract excerpt
The CCAAT/enhancer binding proteins (C/EBPs) are differentially expressed throughout mammary gland development and interact with binding sites within the promoter of a milk protein gene, beta-casein. The specific roles of C/EBPbeta and C/EBPalpha in mouse mammary gland development and differentia...
Topics
- Animals
- Apoptosis
- Blotting, Northern
- CCAAT-Enhancer-Binding Proteins
- Caseins
- Cell Differentiation
- Cell Division
- DNA-Binding Proteins
- Epithelial Cells
- Epithelium
- Estrogens
- Female
- Gene Deletion
- Gene Expression
- Male