Article
Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae.
Genetics - 1 Jun 1999
Hardwick K G, Li R, Mistrot C, Chen R H, Dann P, Rudner A, Murray A W
Abstract excerpt
The spindle checkpoint arrests cells in mitosis in response to defects in the assembly of the mitotic spindle or errors in chromosome alignment. We determined which spindle defects the checkpoint can detect by examining the interaction of mutations that compromise the checkpoint (mad1, mad2, and mad3) with those that damage various structural components of the spindle. Defects in microtubule polymerization,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.