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Article

Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant.

Nucleic acids research - 1 Jan 2005

Luna Luisa, Rolseth Veslemøy, Hildrestrand Gunn A, Otterlei Marit, Dantzer Françoise, Bjørås Magnar, Seeberg Erling

Abstract excerpt

Numerous lines of evidence support the role of oxidative stress in different types of cancer. A major DNA lesion, 8-oxo-7,8-dihydroguanine (8-oxoG), is formed by reactive oxygen species in the genome under physiological conditions. 8-OxoG is strongly mutagenic, generating G.C-->T.A transversions, a frequent somatic mutation in cancers. hOGG1 was cloned as a gene encoding a DNA glycosylase that specifically...

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Identifiers

PMID: 15800211
DOI: 10.1093/nar/gki325
PMCID: PMC1072800

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