Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.

doi:10.1038/sj.onc.1201872

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Article

Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.

Oncogene - 25 Jun 1998

Kohno T, Shinmura K, Tosaka M, Tani M, Kim S R, Sugimura H, Nohmi T, Kasai H, Yokota J

Abstract excerpt

The hOGG1 gene encodes a DNA glycosylase that excises 8-hydroxyguanine (oh8Gua) from damaged DNA. Structural analyses of the hOGG1 gene and its transcripts were performed in normal and lung cancer cells. Due to a genetic polymorphism at codon 326, hOGG1-Ser326 and hOGG1-Cys326 proteins were produ...

Topics

8-Hydroxy-2'-Deoxyguanosine
Alleles
Alternative Splicing
Cell Line
Codon
Cysteine
DNA
DNA Damage
DNA Repair
DNA-Formamidopyrimidine Glycosylase
Deoxyguanosine
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes

Genetic Variation

Genotype

Humans

Leukocytes, Mononuclear

Loss of Heterozygosity

Source

Open in PubMed

Identifiers

PMID: 9681819
DOI: 10.1038/sj.onc.1201872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9681819-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.PMID 9681819Read ↗

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