Rapid detection of the hOGG1 Ser326Cys polymorphism using LightCycler technology.

doi:10.1080/15287390801988038

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Article

Rapid detection of the hOGG1 Ser326Cys polymorphism using LightCycler technology.

Journal of toxicology and environmental health. Part A - 1 Jan 2008

Rihs Hans-Peter, Marczynski Boleslaw, Rabstein Sylvia, Scherenberg Michael, Landt Olfert, Bruning Thomas

Abstract excerpt

Human 8-oxoguanine DNA glycosylase 1 (hOGG1) plays an important role in the repair of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodGuo), one of the major constituents in DNA damage. A recent in vitro study showed that the hOGG1 326Cys polymorphism (rs1052133) exhibits reduced 8-oxodGuo repair activity. This study aimed to develop a LightCycler (LC) assay to analyze the C>G polymorphism (Ser326Cys) in exon 7 of the...

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PMID: 18569589
DOI: 10.1080/15287390801988038

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