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The 8-oxoguanine DNA N-glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease.

Cell biochemistry and function - 1 Apr 2011

Tanrikulu Sevda, Doğru-Abbasoğlu Semra, Ozderya Ayşenur, Ademoğlu Evin, Karadağ Berrin, Erbil Yeşim, Uysal Müjdat

Abstract excerpt

Oxidative DNA damage, caused by either endogenous or exogenous sources of reactive oxygen species (ROS), has been linked several diseases including Graves' disease (GD). 7,8-Dihydro-8-oxoguanine (8-oxoG) is a major lesion produced by ROS and is considered a key biomarker of oxidative DNA damage. In humans, 8-oxoG is mainly repaired by 8-oxoguanine DNA N-glycosylase-1 (hOGG1), which is an essential component of...

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PMID: 21465496
DOI: 10.1002/cbf.1742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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