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Article

Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo.

Carcinogenesis - 1 Sept 2004

Yamane Arito, Kohno Takashi, Ito Kohei, Sunaga Noriaki, Aoki Kazunori, Yoshimura Kimio, Murakami Hirokazu, Nojima Yoshihisa, Yokota Jun

Abstract excerpt

OGG1 protein has an ability to suppress mutagenesis induced by 8-hydroxyguanine (8OHG), an oxidatively damaged promutagenic base. Here, the mutation suppressive ability was compared between two common polymorphic OGG1 proteins, OGG1-Ser326 and OGG1-Cys326, using a supF forward mutation assay employing an 8OHG-containing plasmid. Polymorphic OGG1 proteins were exogenously expressed by adenoviral transduction in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15073047
DOI: 10.1093/carcin/bgh166

Genes

OGG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo.PMID 15073047Read ↗

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The effect of hOGG1 Ser326Cys polymorphism on cancer risk: evidence from a meta-analysis.Semantic proximity Read ↗

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