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Article

Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity.

Cancer research - 15 Apr 2009

Bravard Anne, Vacher Monique, Moritz Eva, Vaslin Laurence, Hall Janet, Epe Bernd, Radicella J Pablo

Abstract excerpt

The hOGG1 gene encodes the DNA glycosylase that removes the mutagenic lesion 7,8-dihyro-8-oxoguanine (8-oxoG) from DNA. A frequently found polymorphism resulting in a serine to cysteine substitution at position 326 of the OGG1 protein has been associated in several molecular epidemiologic studies with cancer development. To investigate whether the variant allele encodes a protein with altered OGG1 function, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19351836
DOI: 10.1158/0008-5472.CAN-08-3943

Genes

OGG1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Oxidation status of human OGG1-S326C polymorphic variant determines cellular DNA repair capacity.PMID 19351836Read ↗

Genotype-phenotype analysis of S326C OGG1 polymorphism: a risk factor for oxidative pathologies.Semantic proximity Read ↗

DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326.Semantic proximity Read ↗

hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.Semantic proximity Read ↗

Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity.Semantic proximity Read ↗

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hOGG1-Cys326 variant cells are hypersensitive to DNA repair inhibition by nitric oxide.Semantic proximity Read ↗

Could 8-oxoguanine DNA glycosylase 1 Ser326Cys polymorphism be a biomarker of susceptibility in cancer?Semantic proximity Read ↗

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