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Article

Analysis of the rat ribosomal DNA promoter: characterization of linker-scanning mutants and of the binding of UBF.

Nucleic acids research - 11 Apr 1992

Xie W, O'Mahony D J, Smith S D, Lowe D, Rothblum L I

Abstract excerpt

To investigate the mechanism of transcription of the rat ribosomal DNA (rDNA) promoter, a series of 23 linker-scanning mutants were constructed and assayed in transfected CHO cells and with cell-free extracts. With minor variation, the results of the in vitro and in vivo assays paralleled one another. For example, these assays demonstrated that the mutagenesis of bases from -133 to -124, and those from -106 to...

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Identifiers

PMID: 1579451
DOI: 10.1093/nar/20.7.1587
PMCID: PMC312242

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Source receipt: pubmed, retrieved 7 Sept 2026.

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