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Article

Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.

Nature - 26 Apr 1990

Jantzen H M, Admon A, Bell S P, Tjian R

Abstract excerpt

The eukaryotic upstream binding factor (UBF), recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor, SL1. Isolation of complementary DNA clones and sequence analysis reveals similarities between DNA binding domains of human UBF (hUBF) and high mobility group (HMG) protein 1. Expression, cellular...

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PMID: 2330041
DOI: 10.1038/344830a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.PMID 2330041Read ↗

The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF.Semantic proximity Read ↗

The HMG box-containing nucleolar transcription factor UBF interacts with a specific subunit of RNA polymerase I.Semantic proximity Read ↗

Both HMG boxes in Hmo1 are essential for DNA binding in vitro and in vivo.Semantic proximity Read ↗

Internal Associations of the Acidic Region of Upstream Binding Factor Control Its Nucleolar Localization.Semantic proximity Read ↗

A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria.Semantic proximity Read ↗

Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system.Semantic proximity Read ↗

Transcription factor regulation of ribosomal RNA in hematopoiesisSemantic proximity Read ↗

Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylationSemantic proximity Read ↗

xUBF contains a novel dimerization domain essential for RNA polymerase I transcription.Semantic proximity Read ↗

Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease.Semantic proximity Read ↗

Oligomerization of Hmo1 mediated by box A is essential for DNA binding in vitro and in vivo.Semantic proximity Read ↗

Bidirectional cooperation between Ubtf1 and SL1 determines RNA Polymerase I promoter recognition <i>in cell</i> and is negatively affected in the UBTF-E210K neuroregression syndromeSemantic proximity Read ↗

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