Article
Complementary in vivo and in vitro analyses of the interactions between the cis-acting elements of the rat rDNA promoter.
Molecular and cellular biochemistry - 1 Jan 2000
Xie W Q, O'Mahony D J, Smith S D, Rothblum L
Abstract excerpt
Two transcription factors, rat UBF (rUBF) and rat SL-1 are required for the efficient transcription of the rat promoter in vitro. In vitro studies have established that two broadly defined cis-acting domains, the core promoter element and the upstream promoter element, cooperate to direct correct transcription by RNA polymerase I. The ability of UBF to bind to two linker-scanning mutants of the upstream promoter...
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