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Article

The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.

Diabetes - 1 Apr 2005

Blankenhorn Elizabeth P, Rodemich Lucy, Martin-Fernandez Cristina, Leif Jean, Greiner Dale L, Mordes John P

Abstract excerpt

BBDR rats develop autoimmune diabetes only after challenge with environmental perturbants. These perturbants include polyinosinic:polycytidylic acid (poly I:C, a ligand of toll-like receptor 3), agents that deplete regulatory T-cell (Treg) populations, and a non-beta-cell cytopathic parvovirus (Kilham rat virus [KRV]). The dominant diabetes susceptibility locus Iddm4 is required for diabetes induced by treatment...

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Source

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Identifiers

PMID: 15793267
DOI: 10.2337/diabetes.54.4.1233
PMCID: PMC2518668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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