Article
Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2003
Zipris Danny, Hillebrands Jan-Luuk, Welsh Raymond M, Rozing Jan, Xie Jenny X, Mordes John P, Greiner Dale L, Rossini Aldo A
Abstract excerpt
Viruses are believed to contribute to the pathogenesis of autoimmune type 1A diabetes in humans. This pathogenic process can be modeled in the BBDR rat, which develops pancreatic insulitis and type 1A-like diabetes after infection with Kilham's rat virus (RV). The mechanism is unknown, but does not involve infection of the pancreatic islets. We first documented that RV infection of BBDR rats induces diabetes,...
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