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Article

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.

Diabetes - 1 Jun 2007

Wallis Robert H, Wang KeSheng, Dabrowski Dominika, Marandi Leili, Ning Terri, Hsieh Eugene, Paterson Andrew D, Mordes John P, Blankenhorn Elisabeth P, Poussier Philippe

Abstract excerpt

OBJECTIVE: The biobreeding diabetes-prone (BBDP) rat spontaneously develops type 1 diabetes. Two of the genetic factors contributing to this syndrome are the major histocompatibility complex (Iddm1) and a Gimap5 mutation (Iddm2) responsible for a T-lymphopenia. Susceptibility to experimentally induced type 1 diabetes is widespread among nonlymphopenic (wild-type Iddm2) rat strains provided they share the BBDP...

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Share to Chromosome Mapping
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

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Share to Genetic Predisposition to Disease

Share to Rats, Inbred BB

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Source

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Identifiers

PMID: 17389329
DOI: 10.2337/db06-1790
PMCID: PMC3987115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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