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Article

Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2009

Mordes John P, Cort Laura, Norowski Elaine, Leif Jean, Fuller Jessica M, Lernmark Ake, Greiner Dale L, Blankenhorn Elizabeth P

Abstract excerpt

Iddm14 (formerly Iddm4) is a non-MHC-linked genetic locus associated with autoimmune diabetes. Its effects have been well-documented in BB-derived rats in which diabetes is either induced by immunologic perturbation or occurs spontaneously. The role of Iddm14 in non-BB rat strains is unknown. Our goal was to extend the analysis of Iddm14 in new diabetes-susceptible strains and to identify candidate genes in the...

Topics

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Diabetes Mellitus, Type 1
Genetic Predisposition to Disease
Haplotypes
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred Strains

Receptors, Antigen, T-Cell, alpha-beta

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Identifiers

PMID: 19205800
DOI: 10.1007/s00335-009-9172-y
PMCID: PMC3962255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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