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Article

The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats.

Diabetes - 1 Nov 2002

Mordes John P, Leif Jean, Novak Stephen, DeScipio Cheryl, Greiner Dale L, Blankenhorn Elizabeth P

Abstract excerpt

Viral antibody-free BBDR and WF rats never develop spontaneous diabetes. BBDR rats, however, develop autoimmune diabetes after perturbation of the immune system, e.g., by viral infection. We previously identified a disease-susceptibility locus in the BBDR rat, iddm4, which is associated with the development of autoimmune diabetes after treatment with polyinosinic:polycytidylic acid and an antibody that depletes...

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Adoptive Transfer
Diabetes Mellitus, Type 1
Disease Models, Animal
Homozygote
Islets of Langerhans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Diseases

Rats, Mutant Strains

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Identifiers

PMID: 12401717
DOI: 10.2337/diabetes.51.11.3254
PMCID: PMC4034451

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