Article
Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.
Diabetes - 1 Jan 1999
Martin A M, Blankenhorn E P, Maxson M N, Zhao M, Leif J, Mordes J P, Greiner D L
Abstract excerpt
BB rats are used as models of autoimmune human IDDM. Genetic control of IDDM in both species is complex, including both major histocompatibility complex (MHC)-linked and non-MHC-linked genes. DP-BB rats develop IDDM spontaneously. Expression of disease in these animals requires homozygosity at th...
Topics
- Animals
- Chromosome Mapping
- Chromosomes, Human, Pair 13
- Chromosomes, Human, Pair 4
- Diabetes Mellitus, Type 1
- Disease Progression
- Genetic Linkage
- Genetic Predisposition to Disease
- Genome
- Humans
- Hybridization, Genetic
- Islets of Langerhans
- Major Histocompatibility Complex
- Pancreatitis