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Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex.

Diabetes - 1 Dec 2009

Blankenhorn Elizabeth P, Cort Laura, Greiner Dale L, Guberski Dennis L, Mordes John P

Abstract excerpt

OBJECTIVE: To identify genes that confer susceptibility to autoimmune diabetes following viral infection in the LEW.1WR1 rat. RESEARCH DESIGN AND METHODS: About 2% of LEW.1WR1 rats develop spontaneous autoimmune diabetes. Immunological perturbants including viral infection increase both the frequency and tempo of diabetes onset. To identify diabetes susceptibility genes (LEW.1WR1 x WF), F2 rats were infected with...

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Parvoviridae Infections
Autoimmunity
Diabetes Mellitus, Type 1
Genetic Linkage
Major Histocompatibility Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred Strains

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Open in PubMed Open full text

Identifiers

PMID: 19720792
DOI: 10.2337/db09-0387
PMCID: PMC2780864

Genes

UBD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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