Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats.

Genes and immunity - 1 Jan 2000

Cort L, Habib M, Eberwine R A, Hessner M J, Mordes J P, Blankenhorn E P

Abstract excerpt

Genetic studies of type 1 diabetes (T1D) have been advanced by comparative analysis of multiple susceptible and resistant rat strains with a permissive class II MHC haplotype, RT1(u). LEW.1WR1 (but not resistant LEW.1W or WF) rats are susceptible to T1D induced by a TLR3 agonist polyinosinic:polycytidylic acid followed by infection with parvovirus. We have mapped genetic loci for virus-induced T1D susceptibility,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 1
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Gene Expression Profiling

Share to Genetic Complementation Test

Share to Mice, Knockout

Share to Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 24452267
DOI: 10.1038/gene.2013.72
PMCID: PMC4260472

Genes

UBD
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats.PMID 24452267Read ↗

Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex.Semantic proximity Read ↗

The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.Semantic proximity Read ↗

Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.Semantic proximity Read ↗

LEW.1WR1 Rats Develop Autoimmune Diabetes Spontaneously and in Response to Environmental PerturbationSemantic proximity Read ↗

T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes.Semantic proximity Read ↗

A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat.Semantic proximity Read ↗

Rat models of type 1 diabetes: genetics, environment, and autoimmunity.Semantic proximity Read ↗

Autoantigen-induced focusing of Vβ13+ T cells precedes onset of autoimmune diabetes in the LEW.1WR1 rat.Semantic proximity Read ↗

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.Semantic proximity Read ↗

The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats.Semantic proximity Read ↗

Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.Semantic proximity Read ↗

UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.