Article
Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats.
Diabetologia - 1 Jul 2000
Ellerman K E, Like A A
Abstract excerpt
AIMS/HYPOTHESIS: We did experiments to explore the pathways putatively leading to Type I (insulin-dependent) diabetes mellitus, and their association with the MHC locus, the major genetic determinant of disease susceptibility. METHODS: Normal MHC congenic rat strains that do not spontaneously develop diabetes or any other autoimmune syndrome were injected with the interferon-alpha inducer...
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