Article
Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
ILAR journal - 1 Jan 2004
Mordes John P, Bortell Rita, Blankenhorn Elizabeth P, Rossini Aldo A, Greiner Dale L
Abstract excerpt
For many years, the vast amount of data gathered from analysis of nonobese diabetic (NOD) and congenic NOD mice has eclipsed interest in the rat for the study of type 1 diabetes. The study of rat models has continued, however, and recently there has been a reanimation of interest for several reasons. First, genetic analysis of the rat has accelerated. Ian4L1, cblb, and Iddm4 are now known to play major roles in...
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