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Article

Protection against bleomycin-induced lung injury by IL-18 in mice.

American journal of physiology. Lung cellular and molecular physiology - 1 Aug 2005

Nakatani-Okuda Akemi, Ueda Haruyasu, Kashiwamura Shin-Ichiro, Sekiyama Atsuo, Kubota Akira, Fujita Yukihisa, Adachi Susumu, Tsuji Yoshiyuki, Tanizawa Takakuni, Okamura Haruki

Abstract excerpt

The role of interleukin (IL)-18 in the protection from interstitial pneumonia and pulmonary fibrosis induced by bleomycin (BLM) was investigated by comparing the severity of BLM-induced lung injuries between wild-type and C57BL/6 mice with a targeted knockout mutation of the IL-18 gene (IL-18-/- mice). IL-18-/- mice showed much worse lung injuries than wild-type mice, as assessed by the survival rate,...

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Source

Identifiers

PMID: 15792964
DOI: 10.1152/ajplung.00380.2004

Genes

BLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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