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Article

Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2000

Monteforte G M, Takeda K, Rodriguez-Sosa M, Akira S, David J R, Satoskar A R

Abstract excerpt

IL-18 has been shown to play a critical role in the development of a Th1 response and immunity against intracellular pathogens. To determine the role of IL-18 in the development of protective immunity against Leishmania major, we have analyzed the course of cutaneous L. major in IL-18-deficient C57BL/6 mice (IL-18-/-) compared with similarly infected wild-type mice (IL-18+/+). After L. major infection, IL-18-/-...

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Source

Identifiers

PMID: 10820270
DOI: 10.4049/jimmunol.164.11.5890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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