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Article

Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12p40.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2002

Kinjo Yuki, Kawakami Kazuyoshi, Uezu Kaori, Yara Satomi, Miyagi Kazuya, Koguchi Yoshinobu, Hoshino Tomoaki, Okamoto Masaki, Kawase Yusuke, Yokota Koichi, Yoshino Kohichiro, Takeda Kiyoshi, Akira Shizuo, Saito Atsushi

Abstract excerpt

The present study was conducted to critically determine the protective role of IL-18 in host response to Mycobacterium tuberculosis infection. IL-18-deficient (knockout (KO)) mice were slightly more prone to this infection than wild-type (WT) mice. Sensitivity of IL-12p40KO mice was lower than th...

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Source

Identifiers

PMID: 12077261
DOI: 10.4049/jimmunol.169.1.323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12077261-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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