Article
Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice.
Experimental lung research - 1 Jan 2000
Ortiz L A, Lasky J, Hamilton R F, Holian A, Hoyle G W, Banks W, Peschon J J, Brody A R, Lungarella G, Friedman M
Abstract excerpt
Bleomycin (BLM) induction of lung fibrosis in mice is an established model to study the mechanism of pulmonary fibrosis. Cytokine secretion has been implicated as a fundamental component of the lung fibrotic process observed in response to BLM. Among the cytokines implicated in lung fibrosis, Tum...
Topics
- Animals
- Bleomycin
- DNA Primers
- Female
- Genotype
- Hydroxyproline
- Immunoenzyme Techniques
- In Situ Hybridization
- Interleukin-1
- Lung
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Pulmonary Fibrosis
- RNA, Messenger
- Receptors, Tumor Necrosis Factor