Article
Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung injury in mice.
Experimental lung research - 1 Jan 2000
Ortiz L A, Lasky J, Hamilton R F, Holian A, Hoyle G W, Banks W, Peschon J J, Brody A R, Lungarella G, Friedman M
Abstract excerpt
Bleomycin (BLM) induction of lung fibrosis in mice is an established model to study the mechanism of pulmonary fibrosis. Cytokine secretion has been implicated as a fundamental component of the lung fibrotic process observed in response to BLM. Among the cytokines implicated in lung fibrosis, Tumor necrosis factor (TNF) alpha has been considered to play a fundamental role. In the present study, we characterized...
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