Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytoprotection by interleukin-6 against liver injury induced by lipopolysaccharide.

International journal of molecular medicine - 1 Feb 2005

Inoue Ken-Ichiro, Takano Hirohisa, Shimada Akinori, Morita Takehito, Yanagisawa Rie, Sakurai Miho, Sato Masahiko, Yoshino Shin, Yoshikawa Toshikazu

Abstract excerpt

The role of interleukin (IL)-6 in inflammatory injury remains controversial. The present study elucidated the role of IL-6 in liver damage during severe inflammation induced by intraperitoneal administration of lipopolysaccharide (LPS; 1 mg/kg) using IL-6 null (-/-) mice and corresponding wild-type (WT) mice. Histological study showed that LPS treatment caused more severe liver injury with centrilobular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lipopolysaccharides
Share to Chemokine CCL2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokines

Share to Cytoprotection

Share to Endotoxins

Share to Enzyme-Linked Immunosorbent Assay

Share to Hepatocytes

Share to Interleukin-6

Source

Identifiers

PMID: 15647834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytoprotection by interleukin-6 against liver injury induced by lipopolysaccharide.PMID 15647834Read ↗

Protective role of interleukin-6 in coagulatory and hemostatic disturbance induced by lipopolysaccharide in mice.Semantic proximity Read ↗

IL-6 Mutation Attenuates Liver Injury Caused by Aeromonas hydrophila Infection by Reducing Oxidative Stress in Zebrafish.Semantic proximity Read ↗

IL-6 knockout alleviates inflammatory response and improve acute lung injury via regulating macrophage polarization in sepsisSemantic proximity Read ↗

Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice.Semantic proximity Read ↗

TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.Semantic proximity Read ↗

The resistance of P. acnes--primed interferon gamma-deficient mice to low-dose lipopolysaccharide-induced acute liver injury.Semantic proximity Read ↗

Increased sensitivity of IL-6-deficient mice to carbon tetrachloride hepatotoxicity and protection with an IL-6 receptor-IL-6 chimera.Semantic proximity Read ↗

Artesunate strongly modulates myeloid and regulatory T cells to prevent LPS-induced systemic inflammation.Semantic proximity Read ↗

Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury.Semantic proximity Read ↗

Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging miceSemantic proximity Read ↗

Inhibition of SIRT6 aggravates p53-mediated ferroptosis in acute lung injury in miceSemantic proximity Read ↗

Role of interleukin-6 in macrophage functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.