Article
Association of tumour necrosis factor alpha variants with the CF pulmonary phenotype.
Thorax - 1 Apr 2005
Yarden J, Radojkovic D, De Boeck K, Macek M, Zemkova D, Vavrova V, Vlietinck R, Cassiman J-J, Cuppens H
Abstract excerpt
BACKGROUND: The pulmonary phenotype in patients with cystic fibrosis (CF), even in those with the same CF transmembrane conductance regulator (CFTR) genotype, is variable and must therefore be influenced by secondary genetic factors as well as environmental factors. Possible candidate genes that modulate the CF lung phenotype may include proinflammatory cytokines. One such protein is tumour necrosis factor alpha...
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