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Article

Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jan 2012

Corvol Harriet, Beucher Julie, Boëlle Pierre-Yves, Busson Pierre-François, Muselet-Charlier Céline, Clement Annick, Ratjen Felix, Grasemann Hartmut, Laki Judith, Palmer Colin N A, Elborn J Stuart, Mehta Anil

Abstract excerpt

BACKGROUND: The clinical course of cystic fibrosis (CF) lung disease varies between patients bearing identical CFTR mutations. This suggests that additional genetic modifiers may contribute to the pulmonary phenotype. The highly conserved ancestral haplotype 8.1 (8.1AH), carried by up to one quarter of Caucasians, comprises linked gene polymorphisms on chromosome 6 that play a key role in the inflammatory...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21993476
DOI: 10.1016/j.jcf.2011.09.006

Genes

FEV
CFTR
LTA
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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