Article
TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression.
Journal of translational medicine - 23 Jan 2013
Shmarina Galina, Pukhalsky Alexander, Petrova Nika, Zakharova Ekaterina, Avakian Lucine, Kapranov Nikolai, Alioshkin Vladimir
Abstract excerpt
BACKGROUND: It is well known that the disease progression in cystic fibrosis (CF) patients may be diverse in subjects with identical mutation in CFTR gene. It is quite possible that such heterogeneity is associated with TNF-α and/or LT-α gene polymorphisms since their products play a key role in inflammation. The aim of the study was to investigate the possible roles of TNF gene polymorphisms in CF disease...
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