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Article

The effect of TGF-β1 polymorphisms on pulmonary disease progression in patients with cystic fibrosis.

BMC pulmonary medicine - 7 May 2022

Trojan T, Alejandre Alcazar Miguel A, Fink G, Thomassen J C, Maessenhausen M V, Rietschel E, Schneider P M, van Koningsbruggen-Rietschel S

Abstract excerpt

BACKGROUND: Transforming Growth Factor-β1 (TGF-β1) is a genetic modifier in patients with cystic fibrosis (CF). Several single nucleotide polymorphisms (SNPs) of TGF-β1 are associated with neutrophilic inflammation, lung fibrosis and loss of pulmonary function. AIM: The aim of this study was to assess the relationship between genetic TGF-β1 polymorphisms and pulmonary disease progression in CF patients....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35525938
DOI: 10.1186/s12890-022-01977-1
PMCID: PMC9080196

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