Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance to Pseudomonas toxin A: a sensitive marker to screen for mutagenic substances using V79 cells.

Mutagenesis - 1 Mar 1992

Suter W, Negro L, Barrera I, Schneider B

Abstract excerpt

The goal of this study was the development of a mutagenicity assay in V79 cells using Pseudomonas toxin A (PTA) as a selective agent and to compare it with the V79/hypoxanthineguaninephosphoribosyl transferase (HGPT) assay. PTA inhibits protein synthesis by covalently modifying elongation factor 2 (EF-2). Mutations in the EF-2 gene, in genes responsible for the modification of EF-2, and also in genes for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Cell Line
Share to Cricetinae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Hypoxanthine Phosphoribosyltransferase

Share to Mutagenicity Tests

Share to Mutation

Share to Ultraviolet Rays

Source

Identifiers

PMID: 1579068
DOI: 10.1093/mutage/7.2.125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance to Pseudomonas toxin A: a sensitive marker to screen for mutagenic substances using V79 cells.PMID 1579068Read ↗

Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress.Semantic proximity Read ↗

Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds.Semantic proximity Read ↗

Piperonyl butoxide mutagenicity in human RSa cells.Semantic proximity Read ↗

Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons.Semantic proximity Read ↗

Antimutagenicity studies of chlorophyllin using the Salmonella arabinose-resistant assay system.Semantic proximity Read ↗

On the bioactivation and genotoxic action of fluoranthene.Semantic proximity Read ↗

Inhibitory effects of the phorbolester TPA and cigarette smoke condensate on the mutagenicity of benzo[a]pyrene in a co-cultivation system.Semantic proximity Read ↗

Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism.Semantic proximity Read ↗

Comparison of mutagenicity results for nine compounds evaluated at the hgprt locus in the standard and suspension CHO assays.Semantic proximity Read ↗

Induction of ouabain-resistance mutation and cycle-dependent transformation of C3H/10T1/2 cells by N-nitroso-2-acetylaminofluorene.Semantic proximity Read ↗

An evaluation of 6 chromosomal mutagens in the AS52/XPRT mutation assay utilizing suspension culture and soft agar cloning.Semantic proximity Read ↗

Toxicity and mutagenicity of 6 anti-cancer drugs in Chinese hamster V79 cells co-cultured with rat hepatocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.