Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds.

doi:10.1093/mutage/5.3.241

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Article

Expression of xenobiotic-metabolizing enzymes in propagatable cell cultures and induction of micronuclei by 13 compounds.

Mutagenesis - 1 May 1990

Glatt H, Gemperlein I, Setiabudi F, Platt K L, Oesch F

Abstract excerpt

Activities of various xenobiotic-metabolizing enzymes were determined in 18 cell lines. Activities of cytochrome P450 reductase, microsomal epoxide hydrolase and glutathione transferase were detectable in all lines. The highest values were similar to the activities found in freshly isolated rat h...

Topics

Animals
Cell Differentiation
Cell Line
Cricetinae
Cricetulus
Enzymes
Epithelium
Humans
Intestines
Liver
Mice
Micronucleus Tests
Mutagens
Mutation
Xenobiotics

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