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Article

An evaluation of 6 chromosomal mutagens in the AS52/XPRT mutation assay utilizing suspension culture and soft agar cloning.

Mutation research - 1 Nov 1993

Oberly T J, Huffman D M, Scheuring J C, Garriott M L

Abstract excerpt

The AS52/XPRT mutation assay was examined for sensitivity in the detection of chromosomal mutagens. 6 compounds identified as chromosomal mutagens in the mouse lymphoma assay (MLA) were tested for mutagenicity in AS52 cells using suspension treatment and soft agar cloning. The 6 compounds were benzo[a]pyrene (BAP), 2-acetylaminofluorene (2AAF), methylmethanesulfonate (MMS), methyl acrylate (MCR), benzoin (BZ),...

Topics

2-Acetylaminofluorene
Acrylates
Aminophenols
Animals
Benzo(a)pyrene
Benzoin
Cell Line
Cloning, Molecular
Hypoxanthine Phosphoribosyltransferase
Methyl Methanesulfonate
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenicity Tests

Mutagens

Mutation

Sensitivity and Specificity

Source

Identifiers

PMID: 7694139
DOI: 10.1016/0165-1218(93)90077-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7694139-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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