Article
On the bioactivation and genotoxic action of fluoranthene.
Archives of toxicology - 1 Jan 1992
Vaca C, Törnqvist M, Rannug U, Lindahl-Kiessling K, Ahnström G, Ehrenberg L
Abstract excerpt
Fluoranthene (FA) was studied with respect to possible mechanisms of its high mutagenicity but low carcinogenicity, in comparison with the corresponding properties of benzo[a]pyrene (BaP), and with regard to the synergism of these two compounds shown by van Duuren and Goldschmidt (J Natl Cancer Inst 56, 1976, 1237). FA and BaP activated by S9 from Aroclor 1254 (PCB)-treated rats induce HPRT mutations in CHO cells...
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