On the bioactivation and genotoxic action of fluoranthene.

doi:10.1007/BF01973383

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Article

On the bioactivation and genotoxic action of fluoranthene.

Archives of toxicology - 1 Jan 1992

Vaca C, Törnqvist M, Rannug U, Lindahl-Kiessling K, Ahnström G, Ehrenberg L

Abstract excerpt

Fluoranthene (FA) was studied with respect to possible mechanisms of its high mutagenicity but low carcinogenicity, in comparison with the corresponding properties of benzo[a]pyrene (BaP), and with regard to the synergism of these two compounds shown by van Duuren and Goldschmidt (J Natl Cancer Inst 56, 1976, 1237). FA and BaP activated by S9 from Aroclor 1254 (PCB)-treated rats induce HPRT mutations in CHO cells...

Topics

Animals
Aroclors
Benzo(a)pyrene
Carcinogens
Chlorodiphenyl (54% Chlorine)
Cytochrome P-450 CYP1A1
Cytochrome P-450 Enzyme System
Dose-Response Relationship, Drug
Enzyme Activation
Fluorenes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Injections, Intraperitoneal

Lymphocytes

Male

Mice

Mice, Inbred Strains

Microsomes, Liver

Source

Open in PubMed

Identifiers

PMID: 1463388
DOI: 10.1007/BF01973383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1463388-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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