Article
Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism.
Mutagenesis - 1 Nov 1997
De Flora S, Camoirano A, Cartiglia C, Ferguson L
Abstract excerpt
Multiple drug resistance (MDR) mechanisms are known to limit the effectiveness of some cancer chemotherapies, probably through enhancing P-glycoprotein-mediated drug efflux from mammalian cells. Similar mechanisms appear to act in other organisms, including bacteria, and may affect not only the t...
Topics
- Acridines
- Aminacrine
- Benzo(a)pyrene
- Calcium Channel Blockers
- Chromates
- Cyclophosphamide
- Dopamine Antagonists
- Dose-Response Relationship, Drug
- Doxorubicin
- Drug Resistance, Multiple
- Fluorenes
- Indoles
- Mutagenesis
- Mutagenicity Tests
- Mutagens
- Mutation
- Nicotine
- Nitrogen Mustard Compounds