Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism.

Mutagenesis - 1 Nov 1997

De Flora S, Camoirano A, Cartiglia C, Ferguson L

Abstract excerpt

Multiple drug resistance (MDR) mechanisms are known to limit the effectiveness of some cancer chemotherapies, probably through enhancing P-glycoprotein-mediated drug efflux from mammalian cells. Similar mechanisms appear to act in other organisms, including bacteria, and may affect not only the toxicity but also the mutagenicity of certain chemicals. At least in some experimental situations, MDR can be overcome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Drug
Share to Doxorubicin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to Indoles

Share to Mutagenesis

Share to Mutagenicity Tests

Share to Mutagens

Share to Mutation

Source

Identifiers

PMID: 9412996
DOI: 10.1093/mutage/12.6.431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism.PMID 9412996Read ↗

Comparison of the efficacy of a phenothiazine and a bisquinaldinium calmodulin antagonist against multidrug-resistant P388 cell lines.Semantic proximity Read ↗

Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.Semantic proximity Read ↗

Mutation spectra in Salmonella of analogues of MX: implications of chemical structure for mutational mechanisms.Semantic proximity Read ↗

Evaluation of new 2,2'-dimethyl-5,5'-dipropoxybenzidine- and 3,3'-dipropoxybenzidine-based direct dye analogs for mutagenic activity by use of the Salmonella/mammalian mutagenicity assay.Semantic proximity Read ↗

Mutagenicity and effect on gap-junctional intercellular communication of 4,4'-methylenebis(2-chloroaniline) and its oxidized metabolites.Semantic proximity Read ↗

Protection by inhibitors of multidrug resistance against mitochondrial mutagenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Evaluation of 4-hydroxymethylbiphenyl (4HMB), 4-chloromethylbiphenyl (4CMB) and benzyl chloride (BC) using the Ames Salmonella/microsome incorporation test for mutagenicity.Semantic proximity Read ↗

4-Chloromethylbiphenyl, 4-hydroxymethylbiphenyl and benzyl chloride: a comparison of mutagenic potential using the Salmonella reverse mutation assay.Semantic proximity Read ↗

Mutagenic studies on benzyl chloride, 4-chloromethylbiphenyl and 4-hydroxymethylbiphenyl with Salmonella typhimurium as part of the UKEMS trial.Semantic proximity Read ↗

The mutagenic activity of 4-chloromethylbiphenyl (4CMB) and benzyl chloride (BC) in the bacterial/microsome assay.Semantic proximity Read ↗

Food-derived heterocyclic amines potentiate the mutagenicity of a drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX).Semantic proximity Read ↗

Mutagenic activity of 4 active-principle forms of pharmaceutical drugs. Comparative study in the Salmonella typhimurium microsome test, and the HGPRT and Na+/K+ ATPase systems in cultured mammalian cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.