Article
Inhibitory effects of the phorbolester TPA and cigarette smoke condensate on the mutagenicity of benzo[a]pyrene in a co-cultivation system.
Mutation research - 1 Jan 2000
Jongen W M, Hakkert B C, van de Poll M L
Abstract excerpt
The transport of reactive intermediates was studied in a co-cultivation system of primary chick embryo hepatocytes and V79 Chinese hamster cells. Two test systems with different genetic endpoints--sister-chromatid exchange (SCE) and gene mutation at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus--were used. Benzo[a]pyrene (B[a]P) was positive in both test systems. When the V79 cells were...
Topics
- Animals
- Benzo(a)pyrene
- Biotransformation
- Cell Communication
- Chick Embryo
- Cricetinae
- Hypoxanthine Phosphoribosyltransferase
- Intercellular Junctions
- Liver
- Mutation
- Phorbols