Comparison of mutagenicity results for nine compounds evaluated at the hgprt locus in the standard and suspension CHO assays.

doi:10.1093/mutage/6.1.77

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Article

Comparison of mutagenicity results for nine compounds evaluated at the hgprt locus in the standard and suspension CHO assays.

Mutagenesis - 1 Jan 1991

Moore M M, Parker L, Huston J, Harrington-Brock K, Dearfield K L

Abstract excerpt

The Chinese hamster ovary (CHO) assay, which measures newly induced mutations at the hypoxanthine-guanine phosphoribosyltransferase (hgprt) locus, has been widely used for mutagenesis testing. The insensitivity of the standard assay to some genotoxic agents has been speculated to be due to the relatively small number of cells used in the assay. In the present study, we have compared the standard monolayer assay...

Topics

Acrylates
Aminoacridines
Animals
Cell Line
Chromosome Aberrations
Cricetinae
Dose-Response Relationship, Drug
Ethyl Methanesulfonate
Female
Hypoxanthine Phosphoribosyltransferase
Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methyl Methanesulfonate

Mice

Mutagenicity Tests

Mutagens

Mutation

Nitrogen Mustard Compounds

Source

Open in PubMed

Identifiers

PMID: 1710014
DOI: 10.1093/mutage/6.1.77

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1710014-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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