Toxicity and mutagenicity of 6 anti-cancer drugs in Chinese hamster V79 cells co-cultured with rat hepatocytes.

doi:10.1016/0165-1218(85)90115-6

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Article

Toxicity and mutagenicity of 6 anti-cancer drugs in Chinese hamster V79 cells co-cultured with rat hepatocytes.

Mutation research - 1 Jan 2000

Dickins M, Wright K, Phillips M, Todd N

Abstract excerpt

Toxicity and induction of 6-thioguanine-resistant mutants in Chinese hamster V79 cells, co-cultured with or without isolated rate hepatocytes, by 6 anti-cancer drugs (cyclophosphamide, adriamycin, methotrexate, cytosine arabinoside, 6-mercaptopurine and vincristine) were studied. The effect of he...

Topics

Animals
Antineoplastic Agents
Biotransformation
Cell Survival
Cells, Cultured
Cricetinae
Cyclophosphamide
Cytarabine
Dimethylnitrosamine
Doxorubicin
Liver
Mercaptopurine
Methotrexate
Mutation
Rats
Vincristine

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