Article
Piperonyl butoxide mutagenicity in human RSa cells.
Mutation research - 1 Aug 1995
Suzuki H, Suzuki N
Abstract excerpt
Piperonyl butoxide (PB) is used as a pesticide synergist and food additive. Its chemically induced mutagenicity was found in cultured human RSa cells by determination of ouabain-resistant (Ouar) phenotypic mutation, with the highest frequency at the concentration of 0.2 microgram/ml. Moreover, K-ras codon 12 mutations in genomic DNA, analyzed by polymerase chain reaction (PCR) and differential dot-blot...
Topics
- Base Sequence
- Cell Line
- Cell Survival
- DNA
- Drug Resistance
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutagens
- Mutation
- Ouabain
- Phenotype
- Piperonyl Butoxide