Article
Null and conditional semaphorin 3B alleles using a flexible puroDeltatk loxP/FRT vector.
Genesis (New York, N.Y. : 2000) - 1 Apr 2005
van der Weyden Louise, Adams David J, Harris Laura W, Tannahill David, Arends Mark J, Bradley Allan
Abstract excerpt
In neural development, Semaphorin 3B (SEMA3B) is thought to play a role in guiding axons by repulsion. In nonneuronal tissue, SEMA3B has been postulated to be a tumor suppressor gene of lung and breast cancer. Much of the understanding of the function of members of the SEMA3 family has come from targeted deletion of these genes in mice (Sema3A, Sema3C, and Sema3F). Thus, targeted deletion of Sema3B in mice would...
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