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Article

Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.

Genesis (New York, N.Y. : 2000) - 1 Jan 2006

Beard Caroline, Hochedlinger Konrad, Plath Kathrin, Wutz Anton, Jaenisch Rudolf

Abstract excerpt

Transgenic and gene-targeted mutant mice provide powerful tools for analysis of the cellular processes involved in early development and in the pathogenesis of many diseases. Here we describe a transgene integration strategy mediated by site-specific recombination that allows establishment of multiple embryonic stem (ES) cell lines carrying tetracycline-inducible genes targeted to a specific locus to assure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16400644
DOI: 10.1002/gene.20180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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